What Is ACT PRF Technology?
KoreaSkinClinic.net
ACT PRF is an advanced blood-processing technology developed by ExcelBio that combines centrifugation with proprietary physical activation to prepare injectable platelet-rich fibrin (PRF) from a patient’s own blood. Designed for regenerative medicine applications, the system focuses on liquid PRF preparation for clinical use in areas such as skin rejuvenation and hair restoration.
ACT PRF by ExcelBio is an advanced blood-processing technology designed to prepare injectable platelet-rich fibrin (PRF) from a patient’s own blood. By combining centrifugation with proprietary physical activation technology, the ACT PRF system is designed to produce a liquid-form PRF preparation for regenerative medicine applications.
Developed with a focus on processing efficiency and preparation consistency, ACT PRF offers an innovative approach to platelet-based treatments for skin rejuvenation, hair restoration, and other applications involving regenerative medicine.
Table of Contents

Advanced Centrifugation and Physical Activation Technology
The ACT PRF system combines blood-component separation with a specialized physical activation process. This integrated approach is designed to process blood components, including platelets, white blood cells, and fibrin-related material, into a preparation suitable for clinical use under specified conditions.
Its technology platform focuses on the following features:
- Advanced centrifugation: Designed to separate selected blood components during processing.
- Proprietary physical activation: Integrates ExcelBio’s specialized activation technology into the preparation process.
- Liquid PRF preparation: Designed to produce an injectable liquid-form PRF material.
- Anticoagulant-free processing: The manufacturer describes its process as preparing the material without requiring anticoagulants under specified conditions.
- Regenerative medicine applications: Developed for use in platelet- and fibrin-based treatment approaches.
Comparison of Second-Generation Conventional PRF and Third-Generation ExcelBio PRF
| Feature | 2nd-Generation Conventional PRF | 3rd-Generation ExcelBio PRF |
|---|---|---|
| Introduction | Since the 2000s | 2024 onward, according to the manufacturer |
| Form | Membrane or gel | Liquid form; designed for injection |
| Formation Process | Clotting after centrifugation | Manufacturer describes up to 3 hours without clotting under refrigerated conditions after activation |
| Activation Method | Natural coagulation or chemical activation, such as CaCl₂ or thrombin | Physical stress activation using Microtubule technology |
| Growth Factor Release | Gradual, sustained release | Manufacturer claims rapid release at higher concentrations for more than 10 days |
| Intended Applications | Wound healing and tissue repair | Regenerative and aesthetic applications, including skin rejuvenation and hair restoration |
Designed for Skin Rejuvenation and Hair Restoration Applications
ACT PRF technology is intended to support clinical applications that use autologous blood-derived materials. These applications include aesthetic treatments focused on skin quality and selected hair-restoration procedures.
Skin Rejuvenation
PRF-based preparations are used in regenerative aesthetic approaches that aim to support skin quality and tissue-repair processes. Depending on the clinical application, treatment goals may include improving skin texture and the appearance of fine lines.
Hair Restoration
Platelet-based regenerative treatments are being explored for selected types of hair loss. ACT PRF provides a blood-processing platform for preparing PRF-based material for appropriate clinical applications.
A Technology-Focused Approach to PRF Preparation
By integrating centrifugation and proprietary physical activation, ExcelBio ACT PRF offers a specialized approach to liquid PRF preparation. Its system is designed to support healthcare professionals who incorporate autologous blood-derived materials into selected regenerative treatment protocols.
ACT PRF represents ExcelBio’s technology platform for preparing injectable PRF-based materials, bringing together blood-component processing and physical activation in one specialized system.
Who May Benefit from ACT PRF?
| Recommended For | Potential Applications |
|---|---|
| Chronic Skin Conditions and Hair Loss | Supporting skin recovery and exploring regenerative approaches for conditions such as atopic dermatitis and psoriasis, as well as selected hair-loss conditions. |
| Degenerative Joint Conditions and Osteoarthritis | Exploring fibrin-based approaches to support tissue repair and address joint-related symptoms. |
| Burns and Diabetic Foot Ulcers | Investigating tissue repair and healing support in areas affected by significant tissue damage or chronic wounds. |
| Specialized Autologous Blood-Derived Preparations | Exploring personalized preparations using the patient’s own blood components for selected clinical applications. |
FAQs
What is ACT PRF technology?
ACT PRF is a blood-processing technology developed by ExcelBio to prepare injectable platelet-rich fibrin (PRF) from a patient’s own blood. It combines centrifugation with proprietary physical activation for regenerative medicine applications.
How does the ACT PRF system work?
The ACT PRF system uses centrifugation and a specialized physical activation process to separate and process selected blood components, including platelets, white blood cells, and fibrin-related material, into a PRF-based preparation.
What makes ACT PRF different from conventional PRF?
ExcelBio describes ACT PRF as a technology designed to produce an injectable liquid-form PRF preparation under specified conditions. Its approach combines blood-component separation with proprietary physical activation.
What are the applications of ACT PRF?
ACT PRF is designed for PRF-based regenerative applications, including aesthetic skin treatments and selected hair-restoration procedures. The specific application depends on the treatment protocol and the healthcare professional’s assessment.
Does ACT PRF require anticoagulants?
According to ExcelBio, its ACT PRF processing method is designed to prepare the PRF-based material without requiring anticoagulants under specified conditions. The procedure should follow the manufacturer’s instructions for use.
Conclusion: Is ACT PRF Worth Considering in Seoul?
ExcelBio ACT PRF combines advanced centrifugation with proprietary physical activation technology to prepare injectable platelet-rich fibrin (PRF) from a patient’s own blood. Designed for regenerative medicine applications, the system focuses on liquid PRF preparation and the processing of selected blood components for clinical use.
With potential applications in skin rejuvenation and hair restoration, ACT PRF offers healthcare professionals a specialized technology platform for incorporating autologous blood-derived materials into appropriate treatment protocols. By integrating blood-component separation and physical activation, ExcelBio continues to advance its approach to PRF preparation and regenerative aesthetic technology.
References
- ExcelBio. Active PRF — official technology page. Manufacturer descriptions of the ACT PRF processing approach and its stated technical characteristics.
- ExcelBio. ACT PRF product information. Product specifications, listed authorization number, and stated intended use.








